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【文献】基因组脆性位点/Common Fragile Sites

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licheng 发表于 2015-12-24 00:16:06 | 显示全部楼层 |阅读模式
形成原因
http://link.springer.com/journal/18/71/23/page/1
Cellular and Molecular Life Sciences
Volume 71, Issue 23, December 2014
脆性位点综述专辑

http://www.ncbi.nlm.nih.gov/pubmed/25959793
Nat Commun. 2015 May 11;6:7094. doi: 10.1038/ncomms8094.
Oncogenes create a unique landscape of fragile sites.

http://www.ncbi.nlm.nih.gov/pubmed/25937814
Curr Genomics. 2015 Feb;16(1):60-70. doi: 10.2174/1389202916666150114223205.
DNA secondary structure at chromosomal fragile sites in human disease.

http://www.ncbi.nlm.nih.gov/pubmed/25373142
Genome Res. 2015 Feb;25(2):189-200. doi: 10.1101/gr.177121.114. Epub 2014 Nov 4.
Large transcription units unify copy number variants and common fragile sites arising under replication stress.
大于1MB的转录单元和CNV、脆性位点的关系

http://www.ncbi.nlm.nih.gov/pubmed/25238782
Cell Mol Life Sci. 2014 Dec;71(23):4519-44. doi: 10.1007/s00018-014-1717-x. Epub 2014 Sep 20.
Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?
脆性区域富集CTCF位点

http://www.ncbi.nlm.nih.gov/pubmed/22094264
Trends Genet. 2012 Jan;28(1):22-32. doi: 10.1016/j.tig.2011.10.003. Epub 2011 Nov 15.
Common fragile sites: mechanisms of instability revisited.

http://www.ncbi.nlm.nih.gov/pubmed/22195969
Mol Cell. 2011 Dec 23;44(6):966-77. doi: 10.1016/j.molcel.2011.10.013.
Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.

http://www.ncbi.nlm.nih.gov/pubmed/21258320
Nature. 2011 Feb 3;470(7332):120-3. doi: 10.1038/nature09745. Epub 2011 Jan 23.
Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site.

http://www.ncbi.nlm.nih.gov/pubmed/21726815
Mol Cell. 2011 Jul 8;43(1):122-31. doi: 10.1016/j.molcel.2011.05.019.
Failure of origin activation in response to fork stalling leads to chromosomal instability at fragile sites.

http://www.ncbi.nlm.nih.gov/pubmed/22959270
Mol Cell. 2012 Oct 26;48(2):254-65. doi: 10.1016/j.molcel.2012.08.002. Epub 2012 Sep 6.
Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells.

脆性位点图谱
http://www.ncbi.nlm.nih.gov/pubmed/23911288
Cell Rep. 2013 Aug 15;4(3):420-8. doi: 10.1016/j.celrep.2013.07.003. Epub 2013 Aug 1.
Common fragile site profiling in epithelial and erythroid cells reveals that most recurrent cancer deletions lie in fragile sites hosting large genes.

http://www.ncbi.nlm.nih.gov/pubmed/23352430
Cell. 2013 Jan 31;152(3):620-32. doi: 10.1016/j.cell.2013.01.006. Epub 2013 Jan 24.
Identification of early replicating fragile sites that contribute to genome instability.

http://www.ncbi.nlm.nih.gov/pubmed/22456607
Genome Res. 2012 Jun;22(6):993-1005. doi: 10.1101/gr.134395.111. Epub 2012 Mar 28.
A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome?
用基因组序列/修饰特征预测脆性位点

造成的影响
http://www.ncbi.nlm.nih.gov/pubmed/25497101
Cell Rep. 2014 Dec 24;9(6):2001-10. doi: 10.1016/j.celrep.2014.11.022. Epub 2014 Dec 11.
Genomic and functional overlap between somatic and germline chromosomal rearrangements.
生殖细胞和体细胞(癌症)中类似的染色体重排
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