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【CBI特别学术报告】CRISPR screens for precision cancer medicine

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Czh3 发表于 2016-6-26 22:49:22 | 显示全部楼层 |阅读模式
CBI特别学术报告

Time:       10:00-11:00am, Wednesday, June 29, 2016
Location: Room 311, Wang Ke-Zhen Building, Peking University
Speaker: Xiaole Shirley Liu, Professor of Biostatistics and
Computational Biology, Harvard School of Public Health
Title:        CRISPR screens for precision cancer medicine

Abstract:

CRISPR screen is a powerful technique for systematic genetic analysis to identify key genes for tumorigenesis and progression, biomarkers of drug response, and mechanisms underlying drug resistance. However, there are still many computational analysis challenges for experimental biologists to adopt the technology, including how to design a good gRNA library, how to analyze the CRISPR screen data, how to prioritize the CRISPR screen hits for functional validation, and how to model and visualize screen results in multiple conditions. I will discuss a number of computational and statistical methods we developed to overcome these challenges. I will also discuss our experimental efforts for using primary and secondary screens to identify synthetic lethal genes and understand the mechanism underlying the hormone-independent growth and metastasis of breast cancer.

Speaker Bio:

X. Shirley Liu received a PhD in Biomedical Informatics and a PhD minor in Computer Science from Stanford University in 2002. She is a Professor with the Department of Biostatistics and Computational Biology at the Dana-Farber Cancer Institute and Harvard School of Public Health. Shirley is a computational biologist with expertise in cancer epigenetics. Her research focuses on algorithm development and integrative mining from big data generated on microarrays, massively parallel sequencing, and other high throughput techniques to model the specificity and function of transcription factors, chromatin regulators and lncRNAs in tumor development, progression, drug response and resistance.
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