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【文献】肺癌基因组研究

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licheng 发表于 2016-3-18 11:25:53 | 显示全部楼层 |阅读模式
单细胞测序
http://www.ncbi.nlm.nih.gov/pubmed/26084335
Genome Biol. 2015 Jun 19;16:127. doi: 10.1186/s13059-015-0692-3.
Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells.

http://www.ncbi.nlm.nih.gov/pubmed/25887790
Genome Biol. 2015 Apr 3;16:66. doi: 10.1186/s13059-015-0636-y.
Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment.

耐药性
http://www.ncbi.nlm.nih.gov/pubmed/26891683
Nat Commun. 2016 Feb 19;7:10690. doi: 10.1038/ncomms10690.
Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells.

http://www.ncbi.nlm.nih.gov/pubmed/26828195
Nat Med. 2016 Mar;22(3):262-9. doi: 10.1038/nm.4040. Epub 2016 Feb 1.
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition.

PDX模型
http://www.ncbi.nlm.nih.gov/pubmed/26980748
Oncotarget. 2016 Mar 9. doi: 10.18632/oncotarget.8014. [Epub ahead of print]
Whole transcriptome profiling of patient-derived xenograft models as a tool to identify both tumor and stromal specific biomarkers.

早期诊断
http://www.ncbi.nlm.nih.gov/pubmed/26525104
Cancer Cell. 2015 Nov 9;28(5):666-76. doi: 10.1016/j.ccell.2015.09.018. Epub 2015 Oct 29.
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.



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